The APOB polymorphism rs1801701 A/G (p.R3638Q) is an independent risk factor for early-onset coronary artery disease: Data from a Spanish cohort

The APOB polymorphism rs1801701 A/G (p.R3638Q) is an independent risk factor for early-onset coronary artery disease: Data from a Spanish cohort

Apoliprotein B (ApoB) has been associated with hypercholesterolemia and ischemic coronary disease. This study was aimed to determine the effect of two APOB gene variants in the risk of developing early-onset coronary artery disease (EO-CAD) in a Spanish population. The association of these polymorph...

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Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-05, Vol.31 (5), p.1564-1568
Hauptverfasser: Coto, Eliecer, Lorca, Rebeca, Rodríguez-Reguero, Julián, Martín, María, Pascual, Isaac, Avanzas, Pablo, Cuesta-Llavona, Elías, Vázquez-Coto, Daniel, Díaz-Corte, Carmen, Tranche, Salvador, Alonso, Belén, Iglesias, Sara, Morís, César, Gómez, Juan
Format: Artikel
Sprache:eng
Schlagworte:
alleles
angiography
APOB
Atherosclerosis
Coronary artery disease
females
Gene polymorphisms
Genetic association
genotype
genotyping
hypercholesterolemia
males
metabolism
nutrition
regression analysis
risk factors
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Zusammenfassung:Apoliprotein B (ApoB) has been associated with hypercholesterolemia and ischemic coronary disease. This study was aimed to determine the effect of two APOB gene variants in the risk of developing early-onset coronary artery disease (EO-CAD) in a Spanish population. The association of these polymorphisms with hypercholesterolemia was also analysed. The study involved a total of 889 healthy population controls (397 male) and 790 EO-CAD cases (636 male; EO-CAD was defined as male
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2021.02.010