Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis
Background Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic...
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Veröffentlicht in: | Digestive diseases and sciences 2022-04, Vol.67 (4), p.1303-1310 |
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Sprache: | eng |
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Zusammenfassung: | Background
Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis.
Aim
To evaluate the association between PVT and other demographic and clinical factors and pouchitis.
Methods
We used Explorys Inc., a population-based database, to search medical records between 1999 and 2020 with SNOMED-CT code criteria for “construction of pouch” and “ileal pouchitis.” Patients with pouchitis were compared to those with previous pouch construction without pouchitis. Factors associated with pouchitis identified with univariable analysis were introduced into a multivariable model. A post hoc analysis further stratified demographical findings of the association between PVT and pouchitis.
Results
We identified 7900 patients with ileal pouchitis (7.5%) and 97,510 with pouch construction without pouchitis. In multivariate binary logistic regression, adjusted odds ratio (aOR) for the risk of pouchitis in patients with PVT was 10.78 (95% confidence interval [CI] 7.04–16.49,
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ISSN: | 0163-2116 1573-2568 |
DOI: | 10.1007/s10620-021-06969-5 |