Experiences affect social behaviors via altering neuronal morphology and oxytocin system

Life experiences, such as maternal deprivation (MD) and environment enrichment (EE), affect social behaviors in the adult. But, the underlying mechanism remains unclear. In the present study, we determined whether neonatal MD induces social deficits, whether postweaning EE restores the deficits, and their effects on neuron morphology and oxytocin (OT)-oxytocin receptor (OTR) system. We found that MD induced repetitive behavior and deficits in novel object recognition and sociability, and EE alleviated these deficits. MD decreased oxytocinergic neurons in the magnocellular hypothalamic paraventricular nucleus (mPVH), which was parallel to the increased OTR levels and dendritic branches of projection neurons in the basolateral amygdala (BLA). EE increased the OTR levels in the prelimbic cortex (PL) and the oxytocinergic neurons in the parvocellular PVH (vPVH), which were parallel to the increased dendritic branches of small pyramidal neurons in the PL and synaptic connections marked with synaptophysin and postsynaptic density protein 95 in the BLA and PL. Together, the results suggest that postweaning EE alleviates the social impairments induced by neonatal MD and OT-OTR system are experience-dependent and associated with social behaviors and neuron morphology. [Display omitted] •Maternal deprivation (MD) increases dendrites of projection neurons in the BLA.•MD increases oxytocin (OT) receptor levels in the BLA but decreases mPVH OT levels.•Environmental enrichment (EE) increases dendrites of pyramidal neurons in the PL.•EE increases OT neurons in the vPVH and synaptic connections in the BLA and PL.•EE decreases OT receptor levels of BLA and restores social deficits induced by MD.