Modified intramuscular adipose tissue content as a feasible surrogate marker for malnutrition in gastrointestinal cancer

Myosteatosis is gathering attention as a feasible indicator for sarcopenia and increased risk of morbidity. However, the prognostic value of intramuscular adipose tissue content (IMAC) as an assessment method for myosteatosis remains controversial. The objectives of this study are to compare the pro...

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Veröffentlicht in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-05, Vol.40 (5), p.2640-2653
Hauptverfasser: Kusunoki, Yukina, Okugawa, Yoshinaga, Toiyama, Yuji, Kusunoki, Kurando, Ichikawa, Takashi, Ide, Shozo, Shimura, Tadanobu, Kitajima, Takahito, Imaoka, Hiroki, Fujikawa, Hiroyuki, Yasuda, Hiromi, Yokoe, Takeshi, Okita, Yoshiki, Mochiki, Ikuyo, Ohi, Masaki, McMillan, Donald C., Nakatani, Kaname, Kusunoki, Masato
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Sprache:eng
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Zusammenfassung:Myosteatosis is gathering attention as a feasible indicator for sarcopenia and increased risk of morbidity. However, the prognostic value of intramuscular adipose tissue content (IMAC) as an assessment method for myosteatosis remains controversial. The objectives of this study are to compare the prognostic value of intramuscular adipose tissue content (IMAC) with our newly-developed modified IMAC (mIMAC), and to assess the clinical significance of mIMAC in colorectal cancer (CRC) and gastric cancer (GC). We evaluated 892 patients with CRC or GC, and assessed preoperative IMAC and mIMAC to compare their prognostic and predictive values for postoperative infectious complications in both cohorts. Both preoperative IMAC and mIMAC were sex- and disease-dependent, and positively or negatively correlated with age in CRC and GC patients (IMAC: CRC: r = 0.33, P 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2021.03.036