Current knowledge and management of portal vein thrombosis in cirrhosis

Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgica...

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Veröffentlicht in:Journal of hepatology 2021-08, Vol.75 (2), p.442-453
Hauptverfasser: Senzolo, Marco, Garcia-Tsao, Guadalupe, García-Pagán, Juan Carlos
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container_title Journal of hepatology
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creator Senzolo, Marco
Garcia-Tsao, Guadalupe
García-Pagán, Juan Carlos
description Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.
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Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. 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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Cirrhosis
Coagulopathy
Epidemiology
Humans
Incidence
Liver cirrhosis
Liver Cirrhosis - complications
Liver transplantation
Portal hypertension
Portal vein
Portal Vein - abnormalities
Portal Vein - diagnostic imaging
Portal vein thrombosis
Risk Factors
Thrombolysis
Thrombosis
TIPS
Transplant
Venous Thrombosis - classification
Venous Thrombosis - etiology
Venous Thrombosis - physiopathology
title Current knowledge and management of portal vein thrombosis in cirrhosis
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