Current knowledge and management of portal vein thrombosis in cirrhosis
Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgica...
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Veröffentlicht in: | Journal of hepatology 2021-08, Vol.75 (2), p.442-453 |
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creator | Senzolo, Marco Garcia-Tsao, Guadalupe García-Pagán, Juan Carlos |
description | Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis. |
doi_str_mv | 10.1016/j.jhep.2021.04.029 |
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Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2021.04.029</identifier><identifier>PMID: 33930474</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cirrhosis ; Coagulopathy ; Epidemiology ; Humans ; Incidence ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver transplantation ; Portal hypertension ; Portal vein ; Portal Vein - abnormalities ; Portal Vein - diagnostic imaging ; Portal vein thrombosis ; Risk Factors ; Thrombolysis ; Thrombosis ; TIPS ; Transplant ; Venous Thrombosis - classification ; Venous Thrombosis - etiology ; Venous Thrombosis - physiopathology</subject><ispartof>Journal of hepatology, 2021-08, Vol.75 (2), p.442-453</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. 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Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.</description><subject>Cirrhosis</subject><subject>Coagulopathy</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver transplantation</subject><subject>Portal hypertension</subject><subject>Portal vein</subject><subject>Portal Vein - abnormalities</subject><subject>Portal Vein - diagnostic imaging</subject><subject>Portal vein thrombosis</subject><subject>Risk Factors</subject><subject>Thrombolysis</subject><subject>Thrombosis</subject><subject>TIPS</subject><subject>Transplant</subject><subject>Venous Thrombosis - classification</subject><subject>Venous Thrombosis - etiology</subject><subject>Venous Thrombosis - physiopathology</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaLZJ_0APwZBLL3ZGH5a10EtZ2rQQyCU5C1kaZ-XY1layU_LvI7NpDz30NAzzvC_DQ8gnChUFKq_7qt_joWLAaAWiArZ9RzZUApQgBT0hmwypUrFGnZEPKfUAwGEr3pMzzrccRCM25Ga3xIjTXDxN4feA7hELM7liNJN5xHE9hK44hDiboXhGPxXzPoaxDcmnIm_Wx7hflwty2pkh4ce3eU4evn-73_0ob-9ufu6-3pZWMDWXynIDQoKpG-coxRpRtsJZyoRQ3AEK1wgQgtOWGiWYMzXvjHGiNZ1teM3Pyedj7yGGXwumWY8-WRwGM2FYkmY1AyW5aiCjV_-gfVjilL_LlFQcpGyaTLEjZWNIKWKnD9GPJr5oCnrVrHu9atarZg1CZ805dPlWvbQjur-RP14z8OUIYHbx7DHqZD1OFp2PaGftgv9f_yvq5o2w</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Senzolo, Marco</creator><creator>Garcia-Tsao, Guadalupe</creator><creator>García-Pagán, Juan Carlos</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6175-8216</orcidid></search><sort><creationdate>202108</creationdate><title>Current knowledge and management of portal vein thrombosis in cirrhosis</title><author>Senzolo, Marco ; Garcia-Tsao, Guadalupe ; García-Pagán, Juan Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8c3a0460a57dd11e5ee6b4dc124483d0e4d7404431b1a842da53faad4bafc7353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cirrhosis</topic><topic>Coagulopathy</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver transplantation</topic><topic>Portal hypertension</topic><topic>Portal vein</topic><topic>Portal Vein - abnormalities</topic><topic>Portal Vein - diagnostic imaging</topic><topic>Portal vein thrombosis</topic><topic>Risk Factors</topic><topic>Thrombolysis</topic><topic>Thrombosis</topic><topic>TIPS</topic><topic>Transplant</topic><topic>Venous Thrombosis - classification</topic><topic>Venous Thrombosis - etiology</topic><topic>Venous Thrombosis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senzolo, Marco</creatorcontrib><creatorcontrib>Garcia-Tsao, Guadalupe</creatorcontrib><creatorcontrib>García-Pagán, Juan Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senzolo, Marco</au><au>Garcia-Tsao, Guadalupe</au><au>García-Pagán, Juan Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current knowledge and management of portal vein thrombosis in cirrhosis</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>75</volume><issue>2</issue><spage>442</spage><epage>453</epage><pages>442-453</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33930474</pmid><doi>10.1016/j.jhep.2021.04.029</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6175-8216</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cirrhosis Coagulopathy Epidemiology Humans Incidence Liver cirrhosis Liver Cirrhosis - complications Liver transplantation Portal hypertension Portal vein Portal Vein - abnormalities Portal Vein - diagnostic imaging Portal vein thrombosis Risk Factors Thrombolysis Thrombosis TIPS Transplant Venous Thrombosis - classification Venous Thrombosis - etiology Venous Thrombosis - physiopathology |
title | Current knowledge and management of portal vein thrombosis in cirrhosis |
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