Streptozotocin‐Induced Diabetic Models in Mice and Rats

Streptozotocin‐Induced Diabetic Models in Mice and Rats

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also...

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Veröffentlicht in:Current protocols 2021-04, Vol.1 (4), p.e78-n/a
1. Verfasser: Furman, Brian L.
Format: Artikel
Sprache:eng
Schlagworte:
high‐fat
hyperglycemia
insulin deficiency
insulin resistance
insulitis
mouse or rat
nicotinamide
streptozotocin
type 1 diabetes mellitus
type 2 diabetes mellitus
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Zusammenfassung:Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2021 The Authors.
ISSN:2691-1299
2691-1299
DOI:10.1002/cpz1.78