Effective easing of the side effects of copper intrauterine devices using ultra-fine-grained Cu-0.4Mg alloy

Copper intrauterine device is one of the most adopted contraceptive methods with high effectiveness (over 99 %), low cost, spontaneous reversibility and long-lasting usage. However, the side effects induced from the initial burst release of copper ions (Cu2+) hinder the continuation of the Cu-IUD ma...

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Veröffentlicht in:	Acta biomaterialia 2021-07, Vol.128, p.523-539
Hauptverfasser:	Fan, Qianqian, Bao, Guo, Ge, Dongfeng, Wang, Kun, Sun, Mingming, Liu, Tingting, Liu, Jianing, Zhang, Zechuan, Xu, Xiangbo, Xu, Xiaoxue, He, Bin, Rao, Jiancun, Zheng, Yufeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biocorrosion Biological activity Burst release rate Cell lines Contraceptives Copper Copper base alloys Copper-magnesium alloy Corrosion Corrosion prevention Cytotoxicity Electron backscatter diffraction Equal channel angular pressing Intrauterine devices Intrauterine implantation IUD Magnesium Side effects Toxicity Transmission electron microscopy Ultrafine grained bulk copper Ultrafines Uterus
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