Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field. In this review, the design and fabrication methods of injectable dual crosslinking hydrogels are summarized on the basis of previous studies. This review also describes the applications of current hydrogels in biomedical fields. Meanwhile, the future broaden applications of hydrogels are prospected, but the problems and challenges in the development of hydrogels are also put forward.