How NS1 Antibodies Prevent Severe Flavivirus Disease

How NS1 Antibodies Prevent Severe Flavivirus Disease

The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confe...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2021-07, Vol.46 (7), p.519-521
Hauptverfasser: Ooi, Justin S.G., Lok, Shee-Mei
Format: Artikel
Sprache:eng
Schlagworte:
antibody
flavivirus
nonstructural protein 1 (NS1)
structural biology
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Zusammenfassung:The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2021.03.005