Eligibility for growth hormone therapy in children born small for gestational age is substantially lower than expected

Background Growth hormone therapy is indicated for children who are both born ‘small for gestational age’ (SGA) and do not achieve adequate catch‐up growth (ACUG). Objective To evaluate the actual incidence of infants born SGA and their actual ACUG. Methods Birth weight data from the newborn registr...

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Veröffentlicht in:Clinical endocrinology (Oxford) 2021-08, Vol.95 (2), p.308-314
Hauptverfasser: Lavi, Eran, Shafrir, Asher, Halloun, Rana, Basel, Itai, Eventov Friedman, Smadar, Abu‐Libdeh, Abdulsalam, Shoob, Hanna, Stein‐Zamir, Chen, Zangen, David Haim
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Sprache:eng
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Zusammenfassung:Background Growth hormone therapy is indicated for children who are both born ‘small for gestational age’ (SGA) and do not achieve adequate catch‐up growth (ACUG). Objective To evaluate the actual incidence of infants born SGA and their actual ACUG. Methods Birth weight data from the newborn registry at two hospitals were analysed during four consecutive years. SGA was defined according to WHO parameters and the corresponding Israeli criteria. Follow‐up measurements of height and weight were ed from either the Ministry of Health—child growth follow‐up centres, or their paediatrician clinic. ACUG was declared when the height reached was above −2.5 or −2 standard deviations (SDS) from the mean for age and gender. Results Out of 43 307, only 524 babies in the cohort (1.2%) were SGA (52% of expected). This finding was consistent annually. Out of the 446 SGA born children with available growth data (85%) during 4‐8 years, 405 children (90.8%) reached a height greater than −2SDS and 428 (96%!) reached a height greater than –2.5 SDS. Term children had higher rate of ACUG achievement as compared to preterm 97.2% vs 86.8% (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14489