Infliximab therapy in an infant with Netherton syndrome

We present a patient with Netherton syndrome and severe skin manifestations treated with infliximab. By 6 months of age, the child had intractable pruritus, scaling, dry skin, and generalized eczematous lesions resistant to conventional therapies for atopic dermatitis. Clinical improvement was obser...

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Veröffentlicht in:	Pediatric dermatology 2021-05, Vol.38 (3), p.714-716
Hauptverfasser:	Cicek, Fatih, Cekic, Sukru, Kilic, Sara Sebnem
Format:	Artikel
Sprache:	eng
Schlagworte:	Atopic dermatitis Babies Case reports Child Dermatitis Dermatitis, Atopic Dermatology Eczema Humans Immunotherapy Infant Infants Infliximab Infliximab - therapeutic use Monoclonal antibodies Netherton syndrome Netherton Syndrome - drug therapy Pediatrics Pruritus Skin diseases Skin lesions TNF inhibitors Tumor necrosis factor-α
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Beschreibung
Zusammenfassung:	We present a patient with Netherton syndrome and severe skin manifestations treated with infliximab. By 6 months of age, the child had intractable pruritus, scaling, dry skin, and generalized eczematous lesions resistant to conventional therapies for atopic dermatitis. Clinical improvement was observed following the third infusion of infliximab, and by 12 months of age, the skin lesions completely resolved. Infliximab is a promising option for the management of skin inflammation in Netherton syndrome, even in infants.
ISSN:	0736-8046 1525-1470
DOI:	10.1111/pde.14590