Androgen receptor activation decreases proliferation in thyroid cancer cells

The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective rol...

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Veröffentlicht in:	Journal of cellular biochemistry 2021-09, Vol.122 (9), p.1113-1125
Hauptverfasser:	Jones, Melanie E., O'Connell, Timmy J., Zhao, Hong, Darzynkiewicz, Zgibniew, Gupta, Anvita, Buchsbaum, Joseph, Shin, Edward, Iacob, Codrin, Suslina, Nina, Moscatello, Augustine, Schantz, Stimson, Tiwari, Raj, Geliebter, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen androgen receptor Androgen receptors Androgens Cancer Cell cycle cell cycle checkpoint Cell proliferation Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Malignancy mRNA Neuroendocrine tumors Papillary thyroid cancer Receptor mechanisms Receptors Reduction Thyroid Thyroid cancer Translocation
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Zusammenfassung:	The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective role and that thyroid cancer in men represents an escape from androgen‐mediated cell regulation. The analysis of androgen receptor (AR) expression in patient tissue samples identified a 2.7‐fold reduction in AR expression (p
ISSN:	0730-2312 1097-4644
DOI:	10.1002/jcb.29934