Effects of chronotropic incompetence on exercise capacity in people with heart failure versus age-matched controls

Chronotropic incompetence (CI) is an inability to adequately raise heart rate during physiological stress. We established CI prevalence and exercise capacity in heart failure versus healthy age-matched controls. We conducted a systematic search (1966–July 1, 2020) and meta-analysis of studies report...

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Veröffentlicht in:Heart failure reviews 2022-05, Vol.27 (3), p.795-809
Hauptverfasser: NA, Smart, H, Clark, P, Brubaker, KK, Witte, H, Jamil, J, Gierula, HC, Patel, MJ, Pearson
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Sprache:eng
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Zusammenfassung:Chronotropic incompetence (CI) is an inability to adequately raise heart rate during physiological stress. We established CI prevalence and exercise capacity in heart failure versus healthy age-matched controls. We conducted a systematic search (1966–July 1, 2020) and meta-analysis of studies reporting peak VO 2 in people with heart failure with reduced (HFrEF) and preserved (HFpEF) left ventricular ejection fraction and controls. Seventeen studies of 4410 participants were included, 4167 with heart failure and 243 age-matched controls. In both heart failure phenotypes, CI was more prevalent in HFrEF (51.7%) and HFpEF (55.8%) than in healthy controls (9%). Mortality was 24% higher in people with HFrEF and CI versus those with HFrEF and without CI; OR −1.24 (95% CI −2.20 to −0.28; p  = 0.01). People with heart failure and CI had lower peak VO 2 than those without CI (MD) −3.30 ml kg −1  min −1 (95% CI −4.25 to −2.35, p  
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-021-10081-1