Palmitoleic Acid Protects against Hypertension by Inhibiting NF‐κB‐Mediated Inflammation

Scope The role of palmitoleic acid (POA) in hypertension or blood pressure remains uncertain. This study aims to investigate the epidemiological association between circulating POA and primary hypertension in humans, and subsequently evaluate the effects of exogenous POA on blood pressure and aortic...

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Veröffentlicht in:	Molecular nutrition & food research 2021-06, Vol.65 (12), p.e2001025-n/a
Hauptverfasser:	Tang, Jun, Yang, Bo, Yan, Yinkun, Tong, Wenfeng, Zhou, Renke, Zhang, Junhui, Mi, Jie, Li, Duo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Antihypertensive Agents - pharmacology Aorta Aorta - drug effects Aorta - metabolism Aorta - physiopathology aortic remodeling Beijing - epidemiology Blood pressure Blood Pressure - drug effects Case-Control Studies Child Children Cytokines Epidemiology Erythrocytes Erythrocytes - metabolism Fatty Acids, Monounsaturated - blood Fatty Acids, Monounsaturated - pharmacology Female Humans Hypertension Hypertension - blood Hypertension - drug therapy Hypertension - epidemiology Inflammation Inflammation - drug therapy Inflammation - metabolism Male NF-kappa B - metabolism NF‐κB Olive oil Omega‐7 palmitoleic acid Palmitoleic acid Phospholipids Rats Rats, Inbred SHR Regression models Supplements Ventricular Remodeling - drug effects
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Zusammenfassung:	Scope The role of palmitoleic acid (POA) in hypertension or blood pressure remains uncertain. This study aims to investigate the epidemiological association between circulating POA and primary hypertension in humans, and subsequently evaluate the effects of exogenous POA on blood pressure and aortic remodeling in spontaneously hypertensive rats (SHRs). Methods and results A case‐control study of 349 hypertensive and 1396 normotensive children and adolescents is conducted, and found hypertensive cases show significant lower erythrocyte phospholipid POA than normotensive controls (p
ISSN:	1613-4125 1613-4133
DOI:	10.1002/mnfr.202001025