Development of a Matrix Sublimation Device with Controllable Crystallization Temperature for MALDI Mass Spectrometry Imaging

Development of a Matrix Sublimation Device with Controllable Crystallization Temperature for MALDI Mass Spectrometry Imaging

The size and distribution of matrix crystals deposited on the surface of a tissue section play a key role in the performance of MALDI mass spectrometry imaging (MALDI-MSI). In this study, uniform distribution and a restricted size of matrix crystals were achieved via a homemade matrix sublimation de...

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Veröffentlicht in:Analytical chemistry (Washington) 2021-04, Vol.93 (16), p.6342-6347
Hauptverfasser: Xie, Hanyi, Wu, Ri, Hung, Y. L. Winnie, Chen, Xiangfeng, Chan, T.-W. Dominic
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Chemistry
Crystallization
Crystals
Image quality
Ions
Mass spectrometry
Mass spectroscopy
Mussels
Scientific imaging
Spectroscopy
Stability
Strawberries
Sublimation
Subzero temperature
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Beschreibung
Zusammenfassung:The size and distribution of matrix crystals deposited on the surface of a tissue section play a key role in the performance of MALDI mass spectrometry imaging (MALDI-MSI). In this study, uniform distribution and a restricted size of matrix crystals were achieved via a homemade matrix sublimation device with controllable crystallization temperature. The crystallization temperature was stably controlled at a subzero temperature, and homogeneous matrix crystals with diameters
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.1c00260