Beneficial effects of the consumption of sun‐dried radishes (Raphanus sativus cv. YR‐Hyuga‐Risou) on dyslipidemia in apolipoprotein E‐deficient mice

In the present study, we evaluated the effects of daily consumption of raw (RR) or sun‐dried (SDR) radishes (Raphanus sativus cv. YR‐Hyuga‐Risou) on apolipoprotein E‐deficient (ApoE−/−) mice. Daily consumption of RR for 16 weeks significantly decreased body weight gain in the both wild‐type and ApoE−/− mice. The wild‐type mice fed the SDR diet gained significantly less body weight than the ApoE−/− mice fed the same diet, although the ApoE−/− mice showed a trend toward decreased body weight gain. Consumption of both diets led to a marked decrease in visceral fat weight and serum triglyceride levels in ApoE−/− mice. Oral fat tolerance tests indicated that pretreatment with RR or SDR mitigated the increase in serum triglyceride levels seen after oil administration. In conclusion, we found that daily consumption of both RR‐ and SDR‐containing diets can help us to prevent from dyslipidemia by inhibiting fat absorption. Daily consumption of raw radish powder (RR) or sun‐dried radish powder (SDR) protects against dyslipidemia and aberrant blood triglyceride levels. These preventive effects were more apparent in ApoE−/− mice, which indicates that the beneficial effects of RR and SDR consumption may be strongest in the context of severe dyslipidemia.