Can Biomarkers Guide Oncolytic Virus Immunotherapy?

Can Biomarkers Guide Oncolytic Virus Immunotherapy?

Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of...

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Veröffentlicht in:Clinical cancer research 2021-06, Vol.27 (12), p.3278-3279
1. Verfasser: Kaufman, Howard L
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Humans
Immunologic Factors
Immunotherapy
Neoplasms - therapy
Oncolytic Virotherapy
Oncolytic Viruses - genetics
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Zusammenfassung:Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of oncolytic virus immunotherapy in patients with cancer. .
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-21-0660