Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

ABSTRACT Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonist...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2021-05, Vol.85 (6), p.1526-1529
Hauptverfasser: Ojiro, Ichie, Nishio, Hiromi, Yamazaki-Ito, Toyomi, Nakano, Shogo, Ito, Sohei, Toyohara, Yoshikazu, Hiramoto, Tadahiro, Terada, Yuko, Ito, Keisuke
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Sprache:eng
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Zusammenfassung:ABSTRACT Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.
ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbab061