Preoperative Amlodipine Is Efficacious in Preventing Intraoperative HDI in Pheochromocytoma: Pilot RCT

Abstract Context Preoperative blockade with α-blockers is recommended in patients with pheochromocytoma/paraganglioma (PPGL). The data on calcium channel blockade (CCB) in PPGL are scarce. Objective We aimed to compare the efficacy of CCB and α-blockers on intraoperative hemodynamic instability (HDI...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2021-08, Vol.106 (8), p.e2907-e2918
Hauptverfasser:	Jaiswal, Sanjeet Kumar, Memon, Saba Samad, Lila, Anurag, Sarathi, Vijaya, Goroshi, Manjunath, Garg, Robin, Barnabas, Rohit, Hemantkumar, Indrani, Patel, Rajendra D, Oak, Shrikanta, Dalvi, Abhay, Garale, Mahadeo, Patil, Virendra, Shah, Nalini S, Bandgar, Tushar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amlodipine Anesthesia Blood pressure Calcium channels Edema EKG Health aspects Hypertension Hypotension Paraganglioma Phenoxybenzamine Pheochromocytoma Prazosin Tachycardia Telmisartan
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Zusammenfassung:	Abstract Context Preoperative blockade with α-blockers is recommended in patients with pheochromocytoma/paraganglioma (PPGL). The data on calcium channel blockade (CCB) in PPGL are scarce. Objective We aimed to compare the efficacy of CCB and α-blockers on intraoperative hemodynamic instability (HDI) in PPGL. Methods In the interim analysis of this monocentric, pilot, open-label, randomized controlled trial, patients with solitary, secretory, and nonmetastatic PPGL were randomized to oral prazosin gastrointestinal therapeutic system (GITS) (maximum 30 mg, n = 9) or amlodipine (maximum 20 mg, n = 11). The primary outcomes were the episodes and duration of hypertension (systolic blood pressure ≥ 160 mmHg) and hypotension (mean arterial pressure
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgab231