Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. In addition to their efficiency and practicality, mechanochemical reactions are also recognized for their sustainability. The association between mechanochemistry and Green Chemistry often originates from the solvent‐free nature of most mechanochemical protocols, which can reduce waste production. However, mechanochemistry satisfies more than one of the Principles of Green Chemistry. In this Review we will present a series of examples that will clearly illustrate how mechanochemistry can significantly contribute to the fulfillment of Green Chemistry in a more holistic manner. Twelve steps to sustainability: Mechanochemistry is commonly associated to green chemistry for its ability to reduce waste production in chemical synthesis. This Review exemplifies how mechanochemistry touches upon all of the twelve principles of green chemistry.