Association of blood pressure, obesity and physical activity with arterial stiffness in children: a systematic review and meta-analysis

Central pulse wave velocity (cPWV) is a biomarker for cardiovascular (CV) risk and a predictor for CV events in adulthood. Alterations of arterial stiffness have also been associated with CV risk in childhood. The study aimed to systematically review and meta-analyze the association of blood pressur...

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Veröffentlicht in:	Pediatric research 2022-02, Vol.91 (3), p.502-512
Hauptverfasser:	Lona, Giulia, Hauser, Christoph, Köchli, Sabrina, Infanger, Denis, Endes, Katharina, Schmidt-Trucksäss, Arno, Hanssen, Henner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood pressure Blood Pressure - physiology Body mass index Cardiovascular Diseases Child Exercise Humans Hypertension Medicine Medicine & Public Health Meta-analysis Obesity Pediatric Surgery Pediatrics Physical fitness Pulse Wave Analysis Systematic Review Vascular Stiffness
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Zusammenfassung:	Central pulse wave velocity (cPWV) is a biomarker for cardiovascular (CV) risk and a predictor for CV events in adulthood. Alterations of arterial stiffness have also been associated with CV risk in childhood. The study aimed to systematically review and meta-analyze the association of blood pressure (BP), body mass index (BMI), and cardiorespiratory fitness (CRF) with cPWV in children. Literature search was through the databases PubMed, Web of Science, Embase and the Cochrane Register of Controlled Trials. Twenty-two articles were included in the systematic review and eight articles in the meta-analysis. Higher systolic and diastolic BP were associated with higher cPWV (pooled estimated effect size (ES) 0.02 (95% CI: 0.012−0.027; P
ISSN:	0031-3998 1530-0447
DOI:	10.1038/s41390-020-01278-5