Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Clinical trials indicate that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) improve kidney function, yet, the molecular regulation of SGLT2 expression is incompletely understood. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) on SGLT2 expression. In adu...

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Veröffentlicht in:Clinical science (1979) 2021-04, Vol.135 (7), p.943-961
Hauptverfasser: Miyata, Kana N, Lo, Chao-Sheng, Zhao, Shuiling, Liao, Min-Chun, Pang, Yuchao, Chang, Shiao-Ying, Peng, Junzheng, Kretzler, Matthias, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D
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Sprache:eng
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Zusammenfassung:Clinical trials indicate that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) improve kidney function, yet, the molecular regulation of SGLT2 expression is incompletely understood. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) on SGLT2 expression. In adult non-diabetic participants in the Nephrotic Syndrome Study Network (NEPTUNE, n=163), multivariable linear regression analysis showed SGLT2 mRNA was significantly associated with angiotensinogen (AGT), renin, and angiotensin-converting enzyme (ACE) mRNA levels (P
ISSN:0143-5221
1470-8736
DOI:10.1042/CS20210094