Effects of flame retardants on ovarian function

•Flame retardants found in follicular fluid affect ovarian function.•Steroidogenesis and follicular growth are targeted.•Legacy flame retardants induce oxidative stress and inflammatory responses.•Some replacement flame retardants show reduced ovarian toxicity. Flame retardants have been added to a variety of consumer products and are now found ubiquitously throughout the environment. Epidemiological, in vivo, and in vitro studies have shown that polybrominated diphenyl ether (PBDE) flame retardants may have a negative impact on human health; this has resulted in their phase-out and replacement by alternative flame retardants, such as hexabromocyclododecane (HBCDD), tetrabromobisphenol A (TBBPA), and organophosphate esters (OPEs). Evidence suggests that some of these chemicals induce ovarian dysfunction and thus may be detrimental to female fertility; however, the effects of many of these flame retardants on the ovary remain unclear. In this review, we present an overview of the effects of brominated and organophosphate ester flame retardants on ovarian function and discuss the possible mechanisms which may mediate these effects.