Pituitary neuropeptides and B lymphocyte function

Pituitary neuropeptides and B lymphocyte function

This review discusses the accumulated evidence that pro‐opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions....

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Veröffentlicht in:Scandinavian journal of immunology 2021-08, Vol.94 (2), p.e13041-n/a
Hauptverfasser: Benko, Ann L., Wright, A. Dale, Sunyer, Teresa, Kovacs, William J., Olsen, Nancy J.
Format: Artikel
Sprache:eng
Schlagworte:
antibodies/immunoglobulins
B cells
human
Lymphocytes B
Neuropeptides
Pituitary
Prodynorphin
Proenkephalin
Proopiomelanocortin
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Beschreibung
Zusammenfassung:This review discusses the accumulated evidence that pro‐opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions. We also review the available data on receptor systems that might be involved in the transmission of such hormonal signals to B cells.
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.13041