Antimicrobial properties of multifunctional polypyrrole-cobalt oxide-silver nanocomposite against pathogenic bacteria and parasite
Background Conducting polymer based nanocomposites are known to be effective against pathogens. Herein, we report the antimicrobial properties of multifunctional polypyrrole-cobalt oxide-silver nanocomposite (PPy-Co 3 O 4 -AgNPs) for the first time. Antibacterial activities were tested against multi...
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Veröffentlicht in: | Applied microbiology and biotechnology 2021-04, Vol.105 (8), p.3315-3325 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
Conducting polymer based nanocomposites are known to be effective against pathogens. Herein, we report the antimicrobial properties of multifunctional polypyrrole-cobalt oxide-silver nanocomposite (PPy-Co
3
O
4
-AgNPs) for the first time. Antibacterial activities were tested against multi-drug-resistant Gram-negative
Escherichia coli
(
E. coli
) and Gram-positive methicillin-resistant
Staphylococcus aureus
(MRSA) bacteria, while antiamoebic effects were assessed against opportunistic protist
Acanthamoeba castellanii
(
A. castellanii
).
Results
The ternary nanocomposite containing conducting polymer polypyrrole, cobalt oxide, and silver nanoparticles showed potent antimicrobial effects against these pathogens. The antibacterial assay showed that PPy-Co
3
O
4
-AgNPs exhibited significant bactericidal activity against neuropathogenic
E. coli
K1 at only 8 μg/mL as compared to individual components of the nanocomposite, whereas a 70 % inhibition of
A. castellanii
viability was observed at 50 μg/mL. Moreover, PPy-Co
3
O
4
-AgNPs were found to have minimal cytotoxicity against human keratinocytes HaCaT cells in vitro even at higher concentration (50 μg/mL), and also reduced the microbes-mediated cytopathogenicity against host cells.
Conclusion
These results demonstrate that PPy-Co
3
O
4
-AgNPs hold promise in the development of novel antimicrobial nanomaterials for biomedical applications.
Key points
•
Synthesis of polypyrrole-cobalt oxide-silver (PPy-Co
3
O
4
-AgNPs) nanocomposite.
•
Antimicrobial activity of nanocomposite.
•
PPy-Co
3
O
4
-AgNPs hold promise for biomedical applications. |
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ISSN: | 0175-7598 1432-0614 |
DOI: | 10.1007/s00253-021-11221-1 |