Modular, efficient and constant-memory single-cell RNA-seq preprocessing

We describe a workflow for preprocessing of single-cell RNA-sequencing data that balances efficiency and accuracy. Our workflow is based on the kallisto and bustools programs, and is near optimal in speed with a constant memory requirement providing scalability for arbitrarily large datasets. The wo...

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Veröffentlicht in:Nature biotechnology 2021-07, Vol.39 (7), p.813-818
Hauptverfasser: Melsted, Páll, Booeshaghi, A. Sina, Liu, Lauren, Gao, Fan, Lu, Lambda, Min, Kyung Hoi (Joseph), da Veiga Beltrame, Eduardo, Hjörleifsson, Kristján Eldjárn, Gehring, Jase, Pachter, Lior
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Sprache:eng
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