$TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder$

TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder

•Fractionation of seed powder guaraná result a fraction highly active.•Identification of type-A procyanidin trimer by LC-ESI-MS.•High inhibition of TNF-α release in fraction from guaraná.•Strong antioxidant potential was verified in guaraná extracts and fraction. Paullinia cupana Kunth., commonly na...

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Veröffentlicht in:	Food chemistry 2021-09, Vol.355, p.129563-129563, Article 129563
Hauptverfasser:	Machado, Kamilla Nunes, Paula Barbosa, Antony de, de Freitas, Aline Alves, Alvarenga, Luana Farah, Pádua, Rodrigo Maia de, Gomes Faraco, André Augusto, Braga, Fernão Castro, Vianna-Soares, Cristina Duarte, Castilho, Rachel Oliveira
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory Antioxidant Antioxidants - chemistry Brazil Caffeine - chemistry Cell Line Chromatography, High Pressure Liquid Chromatography, Reverse-Phase Guaraná Humans Lipopolysaccharides - pharmacology Monocytes - cytology Monocytes - drug effects Monocytes - metabolism Paullinia - chemistry Paullinia - metabolism Paullinia cupana Plant Extracts - analysis Plant Extracts - chemistry Plant Extracts - pharmacology Proanthocyanidins Seeds - chemistry Seeds - metabolism Spectrometry, Mass, Electrospray Ionization Theobromine - chemistry Theophylline - chemistry TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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