Revisit to the Prognostic Value of Premature Atrial Contraction Burden in 24-h Holter Electrocardiography for Predicting Undiagnosed Atrial Fibrillation ― A Propensity Score-Matched Study

Background:The optimum cut-off value of premature atrial contraction (PAC) burden (CV-PACb) in 24-h Holter electrocardiography (24-h ECG) for predicting atrial fibrillation (AF) is debatable, with few validation data.Methods and Results:We retrospectively analyzed 61 patients already diagnosed with...

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Veröffentlicht in:Circulation Journal 2021/07/21, Vol.85(8), pp.1265-1272
Hauptverfasser: Sasaki, Kenichi, Nakajima, Ikutaro, Higuma, Takumi, Yamada, Marika, Kasagawa, Akira, Togashi, Daisuke, Harada, Tomoo, Akashi, Yoshihiro J.
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Sprache:eng
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Zusammenfassung:Background:The optimum cut-off value of premature atrial contraction (PAC) burden (CV-PACb) in 24-h Holter electrocardiography (24-h ECG) for predicting atrial fibrillation (AF) is debatable, with few validation data.Methods and Results:We retrospectively analyzed 61 patients already diagnosed with AF (AD-AF) and 147 patients never diagnosed with AF (ND-AF), aged ≥50 years, free of heart disease, and who had undergone 24-h ECG and transthoracic echocardiography (TTE). Receiver operating characteristic analysis demonstrated that 0.4% was the optimal CV-PACb differentiating AD-AF from ND-AF, with 69% sensitivity and 72% specificity (area under the curve [AUC] 0.72; 95% confidence interval [CI] 0.65–0.79); however, the left atrial volume index was not significant (AUC 0.60; 95% CI 0.51–0.68). To verify the CV-PACb, new propensity-matched cohorts (i.e., subjects with a PAC burden ≥0.4% and
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-20-1277