Pharmacological Correction of Cisplatin-Induced Hemostatic Disorders

A single intraperitoneal administration of cisplatin in the MTD to outbred female mice disturbed hemostasis and formed the procoagulant phenotype of hemostatic potential on days 7-10 culminating in a pronounced hypocoagulation on day 15. Hemostasis was corrected with warfarin and an extract containi...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2021-03, Vol.170 (5), p.623-626
Hauptverfasser: Filonova, M. V., Fedorova, E. P., Churin, A. A., Kotlovskaya, L. Yu, Solov’ev, M. A., Udut, V. V.
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Sprache:eng
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Zusammenfassung:A single intraperitoneal administration of cisplatin in the MTD to outbred female mice disturbed hemostasis and formed the procoagulant phenotype of hemostatic potential on days 7-10 culminating in a pronounced hypocoagulation on day 15. Hemostasis was corrected with warfarin and an extract containing furocoumarins composed of isopimpinellin (42.97%), bergapten (35.18%), and xanthotoxin (15.41%). The extract was standardized with gas chromatography-mass spectrometry, thin-layer chromatography, and HPLC. Furocoumarins and reference drug warfarin were administered intragastrically during 4 days starting on day 6 after the administration of cisplatin. Both furocoumarins and warfarin corrected hypercoagulation on days 7-10. On day 10, furocoumarins normalized coagulation, whereas warfarin resulted in hypocoagulation. On days 15-30, no effects of warfarin were observed. furocoumarins corrected hypocoagulation on days 15-20 with prolongation of this effect up to experimental day 30.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05119-1