A path analysis model of spiritual well-being and quality of life in Iranian cancer patients: a mediating role of hope

Purpose Maintenance of quality of life (QOL) is vital for adaptation to life-threatening and chronic illnesses such as cancer. Therefore, the evaluation and strengthening of personal psychological resources that support QOL for patients with cancer is paramount. This study investigated the potential mediating role of hope in the relationship between spiritual well-being and QOL in Iranian cancer patients. Methods A correlational predictive design was used with 200 patients with varying types and stage of cancer. Demographic and health characteristic surveys, spiritual well-being (SWB), adult hope, and EORTC QLQ-c30 scales were used for measuring the study constructs. Path analysis modeling was used to determine mediation relationships. Results Patients’ QOL was affected by SWB and hope. Religious (β = 0.205, p = 0.002) and existential (β = 0.286, p < 0.001) SWB dimensions and hope (β = 0.263, p < 0.001) improved QOL scores. The presence of hope partially mediated the relationship between SWB and QOL. Conclusion Quality of life was directly affected by SWB and was further improved by the presence of hope. The study suggests that maintenance of hope is essential to QOL in Iranian patients with cancer.