Clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with lupus nephritis

Objective We investigated the clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with biopsy-proven Class III/IV±V lupus nephritis (LN). Methods Serum VCAM-1 and ICAM-1 levels were determined by ELISAs. Sera from patients with non-renal SLE or non-lupus chronic kidney di...

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Veröffentlicht in:	Lupus 2021-06, Vol.30 (7), p.1039-1050
Hauptverfasser:	Yu, Kelvin YC, Yung, Susan, Chau, Mel KM, Tang, Colin SO, Yap, Desmond YH, Tang, Alexander HN, Ying, Shirley KY, Lee, Cheuk Kwong, Chan, Tak Mao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-DNA antibodies Biopsy Cell activation Creatinine Endothelial cells Hyaluronic acid Inflammation Intercellular adhesion molecule 1 Kidney diseases Lupus Lupus nephritis Nephritis Patients Proteinuria Remission Syndecan Thrombomodulin Vascular cell adhesion molecule 1
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Zusammenfassung:	Objective We investigated the clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with biopsy-proven Class III/IV±V lupus nephritis (LN). Methods Serum VCAM-1 and ICAM-1 levels were determined by ELISAs. Sera from patients with non-renal SLE or non-lupus chronic kidney disease (CKD), and healthy subjects served as controls. Results Seropositivity rate for VCAM-1 and ICAM-1 was 93.10% and 37.93% respectively at the time of nephritic flare, and 44.83% and 13.79% respectively at remission, with both showing higher levels during flare (P
ISSN:	0961-2033 1477-0962
DOI:	10.1177/09612033211004727