Antenatal Fetal Size and Obesity in Five-Year-Old Children in a Large Cohort Created by Data Linkage

What is not well understood is the gestational age at which the fetal size deviates from normal for children who develop obesity. Here we test the hypothesis that large-for-gestational age before birth is associated with increased risk for obesity in early childhood. In this retrospective study, routinely acquired antenatal ultrasound assessments in the first, second, and third trimester were linked to anthropometric measurements at 5.5 years. There were 15,760 individuals, including 678 with obesity, 1955 overweight, and 1254 thin. Compared with children of healthy weight, children who had obesity were shorter in the first trimester [mean difference 0.19 scores (0.10, 0.28)] and heavier in the second [mean difference scores 0.15 (0.03, 0.27)] and third trimester [mean difference scores 0.18 (0.05, 0.32)]. Children in the thin category were lighter compared with children of healthy weight in the third trimester and those in the overweight category were heavier compared with children of healthy weight in the third trimester. All associations were independent of birth weight. The difference in growth trajectories between children who have obesity compared with overweight or thin suggests different underlying mechanisms.