Proharziane and Harziane Derivatives from the Marine Algicolous Fungus Trichoderma asperelloides RR-dl-6-11

One new proharziane and three new harziane derivatives (1–4) together with six known ones (5–10) were isolated from the marine-alga-derived ascomycete Trichoderma asperelloides RR-dl-6-11. Their structures and relative configurations were determined via spectroscopic techniques, and the absolute con...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2021-04, Vol.84 (4), p.1414-1419
Hauptverfasser: Zou, Ji-Xue, Song, Yin-Ping, Zeng, Zhao-Qing, Ji, Nai-Yun
Format: Artikel
Sprache:eng
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Zusammenfassung:One new proharziane and three new harziane derivatives (1–4) together with six known ones (5–10) were isolated from the marine-alga-derived ascomycete Trichoderma asperelloides RR-dl-6-11. Their structures and relative configurations were determined via spectroscopic techniques, and the absolute configurations were ascertained by analysis of ECD curves. This is the first report on the secondary metabolites of T. asperelloides, and the new isolates (1–4), especially seco-harziane 4, greatly add to the structural diversity of harziane diterpenes as well as their precursors and catabolites. Compounds 1–5 inhibited four marine phytoplankton species, and the structure–activity relationship of harziane derivatives is analyzed.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.1c00188