Effects on immunization of the physicochemical parameters of particles as vaccine carriers
•The properties of particles significantly affect the vaccination effect as adjuvants.•Particle sizes affect the extent and type of immune responses.•Particle shapes influence the interaction between immune cells and particles.•Surface chemistry navigates the behaviors of particles in immunization p...
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Veröffentlicht in: | Drug discovery today 2021-07, Vol.26 (7), p.1712-1720 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | •The properties of particles significantly affect the vaccination effect as adjuvants.•Particle sizes affect the extent and type of immune responses.•Particle shapes influence the interaction between immune cells and particles.•Surface chemistry navigates the behaviors of particles in immunization process.
Vaccination has milestone significance for the prophylactic and complete elimination of infectious diseases. However, combating malignant infectious diseases, such as Ebola or HIV, remains a challenge. It is necessary to explore novel technologies to facilitate the immune profile of vaccines. Particles exhibit a remarkable ability to modulate sophisticated immunity because of their intrinsic adjuvanticity or codelivery with immunostimulatory molecules. Recently, particles have been broadly investigated as carriers for vaccine delivery. Their physicochemical parameters (e.g., size, shape, and surface chemistry) significantly influence their in vivo fate and subsequent immunization effect. Herein, we highlight several types of particulate carrier used in the delivery of vaccines. We also examine how to engineer the physical and chemical characteristics of particulate adjuvants to make them robust candidates for a versatile vaccine delivery platform. |
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ISSN: | 1359-6446 1878-5832 |
DOI: | 10.1016/j.drudis.2021.03.007 |