Memories of Harold Scheraga

An obituary for Harold Scheraga, one of the pioneers of protein science and computational biophysics who died on August 1, 2020 at 99-years-old, is presented. Even several months before his death, at the ripe young age of 98, he was planning on submitting his next NIH grant proposal. Scheraga indeed "died funded." The dream of solving the protein folding problem played a major role in Scheraga's life for over 70 years and is evident in the almost 1400 papers he published. He was one of the first to introduce essentially all of the key ideas of protein folding and structure prediction. Whether it was in the development of force fields, statistical potentials, algorithms to solve the multiple minimum problem, homology modeling, coarse grained protein models, or structure prediction using predicted distance matrices personified in the recent breakthrough of AlphaFold 2, Scheraga did the pioneering work.