Impaired Peyer's patch development in BOB.1/OBF.1‐deficient mice

Impaired Peyer's patch development in BOB.1/OBF.1‐deficient mice

BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13‐CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocy...

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Veröffentlicht in:European journal of immunology 2021-07, Vol.51 (7), p.1860-1863
Hauptverfasser: Betzler, Annika C., Fiedler, Katja, Kokai, Enikö, Wirth, Thomas, Hoffmann, Thomas K., Brunner, Cornelia
Format: Artikel
Sprache:eng
Schlagworte:
CXCL13 protein
CXCR5 protein
Dendritic cells
Developmental stages
Lymphocytes B
Organogenesis
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Zusammenfassung:BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13‐CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202048578