Blastocyst-like structures generated from human pluripotent stem cells

Limited access to embryos has hampered the study of human embryogenesis and disorders that occur during early pregnancy. Human pluripotent stem cells provide an alternative means to study human development in a dish 1 – 7 . Recent advances in partial embryo models derived from human pluripotent stem...

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Veröffentlicht in:	Nature (London) 2021-03, Vol.591 (7851), p.620-626
Hauptverfasser:	Yu, Leqian, Wei, Yulei, Duan, Jialei, Schmitz, Daniel A., Sakurai, Masahiro, Wang, Lei, Wang, Kunhua, Zhao, Shuhua, Hon, Gary C., Wu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532 631/532/2064 631/532/2117 Blastocyst Blastocyst - cytology Blastocyst - enzymology Blastocyst - metabolism Blastocysts Cell culture Cell Culture Techniques - methods Cell Differentiation Cell Line Cell Lineage Cell number Cell size Cytology Developmental stages Efficiency Embryo cells Embryogenesis Embryonic development Embryonic growth stage Embryos Gene Expression Regulation, Developmental Gene sequencing Growth factors Human cell culture Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - enzymology Human Embryonic Stem Cells - metabolism Humanities and Social Sciences Humans Implantation Isoenzymes Isoenzymes - metabolism Kinases Methods Morphology multidisciplinary Perturbation Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - enzymology Pluripotent Stem Cells - metabolism Pregnancy Protein kinase C Protein Kinase C - metabolism Science Science (multidisciplinary) Single-Cell Analysis Stem cells Structure Transcriptome Transcriptomics
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