Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis

Sarcopenia worsens survival in patients with advanced liver disease including cirrhosis. In this study, we aimed to characterize skeletal muscle status by dual-energy X-ray absorptiometry (DXA) in patients with cirrhosis and examine the association between different skeletal muscle compartments and...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 2021-05, Vol.320 (5), p.G729-G740
Hauptverfasser: Eriksen, Christian Skou, Kimer, Nina, Suetta, Charlotte, Møller, Søren
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Sprache:eng
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Zusammenfassung:Sarcopenia worsens survival in patients with advanced liver disease including cirrhosis. In this study, we aimed to characterize skeletal muscle status by dual-energy X-ray absorptiometry (DXA) in patients with cirrhosis and examine the association between different skeletal muscle compartments and mortality. We included 231 men and 84 women ( , , and ) with cirrhosis and 315 healthy matched controls (231 men and 84 women). Body composition was assessed with DXA. Appendicular skeletal muscle index (ASMI), arms index (AI), and legs index (LI) were calculated by normalizing lean mass to height squared. Low ASMI was defined as ASMI 
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00478.2020