The clinical features that contribute to poor bone health in young Australians living with cystic fibrosis: A recommendation for BMD screening

Background For Australians living with cystic fibrosis (CF), increased longevity means greater consideration needs to be given to long‐term endocrine sequelae such as CF‐related bone disease. Deficits in bone mass accrual are most likely to occur during childhood and adolescence. Current guidelines...

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Veröffentlicht in:Pediatric pulmonology 2021-07, Vol.56 (7), p.2014-2022
Hauptverfasser: Atlas, Gabby, Yap, Matthew, Lim, Angelina, Vidmar, Suzanna, Smith, Nathan, King, Louise, Jones, Alicia, Hong, Jason, Ranganathan, Sarath, Simm, Peter J.
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Sprache:eng
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Zusammenfassung:Background For Australians living with cystic fibrosis (CF), increased longevity means greater consideration needs to be given to long‐term endocrine sequelae such as CF‐related bone disease. Deficits in bone mass accrual are most likely to occur during childhood and adolescence. Current guidelines in Australia suggest repeat dual‐energy X‐ray absorptiometry (DXA) scans every 2 years. This study aims to stratify clinical factors that determine future bone health in the Australian CF population and use this to guide a more streamlined approach to bone health screening. Methods This study was a retrospective audit of all patients diagnosed with CF who were treated at the Royal Children's Hospital Melbourne, Australia from 2000 to 2016 (n = 453). Two hundred and two patients had a DXA scan in the study period (191 with height‐adjusted data) and 111 patients had more than one scan (108 with height‐adjusted data). An investigation into the associations between bone mineral density (BMD) Z score and potential risk factors was conducted using DXA and historical data. Results The main predictor of future BMD was the previous BMD Z score (p 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25375