On the performance of lung nodule detection, segmentation and classification

•Gives a survey of lung nodule analysis techniques focusing on their performance for clinical applications.•Typical methods of AI-driven lung nodule detection, segmentation, classification and radiomics analysis are reviewed.•Represents the inconformity of annotation and assessment for lung nodules and introduces public datasets. Computed tomography (CT) screening is an effective way for early detection of lung cancer in order to improve the survival rate of such a deadly disease. For more than two decades, image processing techniques such as nodule detection, segmentation, and classification have been extensively studied to assist physicians in identifying nodules from hundreds of CT slices to measure shapes and HU distributions of nodules automatically and to distinguish their malignancy. Thanks to new parallel computation, multi-layer convolution, nonlinear pooling operation, and the big data learning strategy, recent development of deep-learning algorithms has shown great progress in lung nodule screening and computer-assisted diagnosis (CADx) applications due to their high sensitivity and low false positive rates. This paper presents a survey of state-of-the-art deep-learning-based lung nodule screening and analysis techniques focusing on their performance and clinical applications, aiming to help better understand the current performance, the limitation, and the future trends of lung nodule analysis.