Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents

The synthesis of new functionalized tetrazole–pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 “ethyl 1‐((2‐(3‐bromopropyl)‐2H‐tetrazol‐5‐yl)methyl)‐5‐methyl‐1H‐pyrazole‐3‐carboxylate” seems to have the highest effect, which reached 70% at 10−4 M concentration. This effect was partially endothelium‐dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.