Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease
Background and Aim Gut microbiota composition is associated with the pathogenesis of non‐alcoholic fatty liver disease. However, the association between gut microbiota composition and non‐alcoholic fatty liver disease in non‐obese patients remains unclear. We compared clinical parameters and gut mic...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-08, Vol.36 (8), p.2275-2284 |
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| creator | Iwaki, Michihiro Kessoku, Takaomi Ozaki, Anna Kasai, Yuki Kobayashi, Takashi Nogami, Asako Honda, Yasushi Ogawa, Yuji Imajo, Kento Yoneda, Masato Maeda, Ayako Tanaka, Yoshiki Nakajima, Shunji Ohno, Hiroshi Usuda, Haruki Kawanaka, Miwa Kawaguchi, Takumi Torimura, Takuji Kage, Masayoshi Hyogo, Hideyuki Takahashi, Hirokazu Eguchi, Yuichiro Aishima, Shinichi Wada, Koichiro Kobayashi, Noritoshi Sumida, Yoshio Saito, Satoru Nakajima, Atsushi |
| description | Background and Aim
Gut microbiota composition is associated with the pathogenesis of non‐alcoholic fatty liver disease. However, the association between gut microbiota composition and non‐alcoholic fatty liver disease in non‐obese patients remains unclear. We compared clinical parameters and gut microbiota profiles of healthy controls and non‐obese and obese patients with non‐alcoholic fatty liver disease.
Methods
We examined the clinical parameters and gut microbiota profiles by 16S rRNA sequences and short‐chain fatty acid levels in fecal samples from 51 non‐obese patients with non‐alcoholic fatty liver disease (body mass index |
| doi_str_mv | 10.1111/jgh.15487 |
| format | Article |
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Gut microbiota composition is associated with the pathogenesis of non‐alcoholic fatty liver disease. However, the association between gut microbiota composition and non‐alcoholic fatty liver disease in non‐obese patients remains unclear. We compared clinical parameters and gut microbiota profiles of healthy controls and non‐obese and obese patients with non‐alcoholic fatty liver disease.
Methods
We examined the clinical parameters and gut microbiota profiles by 16S rRNA sequences and short‐chain fatty acid levels in fecal samples from 51 non‐obese patients with non‐alcoholic fatty liver disease (body mass index <25 kg/m2) and 51 obese patients with non‐alcoholic fatty liver disease (body mass index ≥30 kg/m2) who underwent pathological examination and 87 controls at five hospitals in Japan.
Results
Although no significant differences between the non‐obese and other groups were observed in alpha diversity, a significant difference was found in beta diversity. We observed a significant decrease in serum alanine aminotransferase levels, Eubacterium population, and butyric acid levels in non‐obese patients with non‐alcoholic fatty liver disease compared with those in obese patients with non‐alcoholic fatty liver disease. A significant negative correlation was found between the stage of hepatic fibrosis and Eubacterium abundance in non‐obese patients with non‐alcoholic fatty liver disease.
Conclusions
The decrease in the abundance of Eubacterium that produces butyric acid may play an important role in the development of non‐alcoholic fatty liver disease in non‐obese individuals. This study was registered at the University Hospital Medical Information Network clinical trial registration system (UMIN000020917).</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15487</identifier><identifier>PMID: 33709477</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Abundance ; Alanine ; Alanine transaminase ; Body mass index ; Butyric Acid ; Eubacterium ; Fatty liver ; Fibrosis ; Gastrointestinal Microbiome ; Gut microbiota ; Hepatic fibrosis ; Humans ; Intestinal microflora ; Liver ; Liver Cirrhosis ; Liver diseases ; Microbiota ; Non-alcoholic Fatty Liver Disease ; Non‐obese NAFLD ; Obesity - complications ; Patients ; RNA, Ribosomal, 16S ; rRNA 16S</subject><ispartof>Journal of gastroenterology and hepatology, 2021-08, Vol.36 (8), p.2275-2284</ispartof><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-e90f798c44e6ee18dedd46712c8f4c445b8765ab1cfb1f4db22d804c7af148d33</citedby><cites>FETCH-LOGICAL-c3537-e90f798c44e6ee18dedd46712c8f4c445b8765ab1cfb1f4db22d804c7af148d33</cites><orcidid>0000-0002-7240-4851 ; 0000-0002-6263-1436 ; 0000-0002-7064-4325 ; 0000-0002-2374-2889 ; 0000-0002-4342-1361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15487$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15487$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33709477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwaki, Michihiro</creatorcontrib><creatorcontrib>Kessoku, Takaomi</creatorcontrib><creatorcontrib>Ozaki, Anna</creatorcontrib><creatorcontrib>Kasai, Yuki</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Nogami, Asako</creatorcontrib><creatorcontrib>Honda, Yasushi</creatorcontrib><creatorcontrib>Ogawa, Yuji</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Maeda, Ayako</creatorcontrib><creatorcontrib>Tanaka, Yoshiki</creatorcontrib><creatorcontrib>Nakajima, Shunji</creatorcontrib><creatorcontrib>Ohno, Hiroshi</creatorcontrib><creatorcontrib>Usuda, Haruki</creatorcontrib><creatorcontrib>Kawanaka, Miwa</creatorcontrib><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Kage, Masayoshi</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Aishima, Shinichi</creatorcontrib><creatorcontrib>Wada, Koichiro</creatorcontrib><creatorcontrib>Kobayashi, Noritoshi</creatorcontrib><creatorcontrib>Sumida, Yoshio</creatorcontrib><creatorcontrib>Saito, Satoru</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><title>Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Gut microbiota composition is associated with the pathogenesis of non‐alcoholic fatty liver disease. However, the association between gut microbiota composition and non‐alcoholic fatty liver disease in non‐obese patients remains unclear. We compared clinical parameters and gut microbiota profiles of healthy controls and non‐obese and obese patients with non‐alcoholic fatty liver disease.
Methods
We examined the clinical parameters and gut microbiota profiles by 16S rRNA sequences and short‐chain fatty acid levels in fecal samples from 51 non‐obese patients with non‐alcoholic fatty liver disease (body mass index <25 kg/m2) and 51 obese patients with non‐alcoholic fatty liver disease (body mass index ≥30 kg/m2) who underwent pathological examination and 87 controls at five hospitals in Japan.
Results
Although no significant differences between the non‐obese and other groups were observed in alpha diversity, a significant difference was found in beta diversity. We observed a significant decrease in serum alanine aminotransferase levels, Eubacterium population, and butyric acid levels in non‐obese patients with non‐alcoholic fatty liver disease compared with those in obese patients with non‐alcoholic fatty liver disease. A significant negative correlation was found between the stage of hepatic fibrosis and Eubacterium abundance in non‐obese patients with non‐alcoholic fatty liver disease.
Conclusions
The decrease in the abundance of Eubacterium that produces butyric acid may play an important role in the development of non‐alcoholic fatty liver disease in non‐obese individuals. This study was registered at the University Hospital Medical Information Network clinical trial registration system (UMIN000020917).</description><subject>Abundance</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Body mass index</subject><subject>Butyric Acid</subject><subject>Eubacterium</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Gastrointestinal Microbiome</subject><subject>Gut microbiota</subject><subject>Hepatic fibrosis</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Liver</subject><subject>Liver Cirrhosis</subject><subject>Liver diseases</subject><subject>Microbiota</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Non‐obese NAFLD</subject><subject>Obesity - complications</subject><subject>Patients</subject><subject>RNA, Ribosomal, 16S</subject><subject>rRNA 16S</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1OxCAUBWBiNDr-LHwBQ-JGF1VoodClMTpqTNzouqFw6zBpy1ioZhIXPoLP6JPIWHVhIhsS7scJ4SC0T8kJjet0_jg7oZxJsYYmlDGSUMHydTQhkvKkyGixhba9nxNCGBF8E21lmSAFE2KCXqdDwK3VvausCwpr1y6ct8G6DivvnbYqgMEvNszwDBYqWI1rW_XReGw73Lnu4-3dVeABr6bQBT_qcaIa7WauWd1SISxxY5-hx8Z6UB520UatGg973_sOeri8uD-_Sm7vptfnZ7eJzngmEihILQqpGYMcgEoDxrBc0FTLmsVTXkmRc1VRXVe0ZqZKUyMJ00LVlEmTZTvoaMxd9O5pAB_K1noNTaM6cIMvU05oyiVnRaSHf-jcDX0XXxcVl4QKkq8Cj0cV_837Hupy0dtW9cuSknJVSRkrKb8qifbgO3GoWjC_8qeDCE5H8GIbWP6fVN5Mr8bITzjwmaY</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Iwaki, Michihiro</creator><creator>Kessoku, Takaomi</creator><creator>Ozaki, Anna</creator><creator>Kasai, Yuki</creator><creator>Kobayashi, Takashi</creator><creator>Nogami, Asako</creator><creator>Honda, Yasushi</creator><creator>Ogawa, Yuji</creator><creator>Imajo, Kento</creator><creator>Yoneda, Masato</creator><creator>Maeda, Ayako</creator><creator>Tanaka, Yoshiki</creator><creator>Nakajima, Shunji</creator><creator>Ohno, Hiroshi</creator><creator>Usuda, Haruki</creator><creator>Kawanaka, Miwa</creator><creator>Kawaguchi, Takumi</creator><creator>Torimura, Takuji</creator><creator>Kage, Masayoshi</creator><creator>Hyogo, Hideyuki</creator><creator>Takahashi, Hirokazu</creator><creator>Eguchi, Yuichiro</creator><creator>Aishima, Shinichi</creator><creator>Wada, Koichiro</creator><creator>Kobayashi, Noritoshi</creator><creator>Sumida, Yoshio</creator><creator>Saito, Satoru</creator><creator>Nakajima, Atsushi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7240-4851</orcidid><orcidid>https://orcid.org/0000-0002-6263-1436</orcidid><orcidid>https://orcid.org/0000-0002-7064-4325</orcidid><orcidid>https://orcid.org/0000-0002-2374-2889</orcidid><orcidid>https://orcid.org/0000-0002-4342-1361</orcidid></search><sort><creationdate>202108</creationdate><title>Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease</title><author>Iwaki, Michihiro ; Kessoku, Takaomi ; Ozaki, Anna ; Kasai, Yuki ; Kobayashi, Takashi ; Nogami, Asako ; Honda, Yasushi ; Ogawa, Yuji ; Imajo, Kento ; Yoneda, Masato ; Maeda, Ayako ; Tanaka, Yoshiki ; Nakajima, Shunji ; Ohno, Hiroshi ; Usuda, Haruki ; Kawanaka, Miwa ; Kawaguchi, Takumi ; Torimura, Takuji ; Kage, Masayoshi ; Hyogo, Hideyuki ; Takahashi, Hirokazu ; Eguchi, Yuichiro ; Aishima, Shinichi ; Wada, Koichiro ; Kobayashi, Noritoshi ; Sumida, Yoshio ; Saito, Satoru ; Nakajima, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-e90f798c44e6ee18dedd46712c8f4c445b8765ab1cfb1f4db22d804c7af148d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abundance</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Body mass index</topic><topic>Butyric Acid</topic><topic>Eubacterium</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Gastrointestinal Microbiome</topic><topic>Gut microbiota</topic><topic>Hepatic fibrosis</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Liver</topic><topic>Liver Cirrhosis</topic><topic>Liver diseases</topic><topic>Microbiota</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Non‐obese NAFLD</topic><topic>Obesity - complications</topic><topic>Patients</topic><topic>RNA, Ribosomal, 16S</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwaki, Michihiro</creatorcontrib><creatorcontrib>Kessoku, Takaomi</creatorcontrib><creatorcontrib>Ozaki, Anna</creatorcontrib><creatorcontrib>Kasai, Yuki</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Nogami, Asako</creatorcontrib><creatorcontrib>Honda, Yasushi</creatorcontrib><creatorcontrib>Ogawa, Yuji</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Maeda, Ayako</creatorcontrib><creatorcontrib>Tanaka, Yoshiki</creatorcontrib><creatorcontrib>Nakajima, Shunji</creatorcontrib><creatorcontrib>Ohno, Hiroshi</creatorcontrib><creatorcontrib>Usuda, Haruki</creatorcontrib><creatorcontrib>Kawanaka, Miwa</creatorcontrib><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Kage, Masayoshi</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Aishima, Shinichi</creatorcontrib><creatorcontrib>Wada, Koichiro</creatorcontrib><creatorcontrib>Kobayashi, Noritoshi</creatorcontrib><creatorcontrib>Sumida, Yoshio</creatorcontrib><creatorcontrib>Saito, Satoru</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwaki, Michihiro</au><au>Kessoku, Takaomi</au><au>Ozaki, Anna</au><au>Kasai, Yuki</au><au>Kobayashi, Takashi</au><au>Nogami, Asako</au><au>Honda, Yasushi</au><au>Ogawa, Yuji</au><au>Imajo, Kento</au><au>Yoneda, Masato</au><au>Maeda, Ayako</au><au>Tanaka, Yoshiki</au><au>Nakajima, Shunji</au><au>Ohno, Hiroshi</au><au>Usuda, Haruki</au><au>Kawanaka, Miwa</au><au>Kawaguchi, Takumi</au><au>Torimura, Takuji</au><au>Kage, Masayoshi</au><au>Hyogo, Hideyuki</au><au>Takahashi, Hirokazu</au><au>Eguchi, Yuichiro</au><au>Aishima, Shinichi</au><au>Wada, Koichiro</au><au>Kobayashi, Noritoshi</au><au>Sumida, Yoshio</au><au>Saito, Satoru</au><au>Nakajima, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>36</volume><issue>8</issue><spage>2275</spage><epage>2284</epage><pages>2275-2284</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Gut microbiota composition is associated with the pathogenesis of non‐alcoholic fatty liver disease. However, the association between gut microbiota composition and non‐alcoholic fatty liver disease in non‐obese patients remains unclear. We compared clinical parameters and gut microbiota profiles of healthy controls and non‐obese and obese patients with non‐alcoholic fatty liver disease.
Methods
We examined the clinical parameters and gut microbiota profiles by 16S rRNA sequences and short‐chain fatty acid levels in fecal samples from 51 non‐obese patients with non‐alcoholic fatty liver disease (body mass index <25 kg/m2) and 51 obese patients with non‐alcoholic fatty liver disease (body mass index ≥30 kg/m2) who underwent pathological examination and 87 controls at five hospitals in Japan.
Results
Although no significant differences between the non‐obese and other groups were observed in alpha diversity, a significant difference was found in beta diversity. We observed a significant decrease in serum alanine aminotransferase levels, Eubacterium population, and butyric acid levels in non‐obese patients with non‐alcoholic fatty liver disease compared with those in obese patients with non‐alcoholic fatty liver disease. A significant negative correlation was found between the stage of hepatic fibrosis and Eubacterium abundance in non‐obese patients with non‐alcoholic fatty liver disease.
Conclusions
The decrease in the abundance of Eubacterium that produces butyric acid may play an important role in the development of non‐alcoholic fatty liver disease in non‐obese individuals. This study was registered at the University Hospital Medical Information Network clinical trial registration system (UMIN000020917).</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33709477</pmid><doi>10.1111/jgh.15487</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7240-4851</orcidid><orcidid>https://orcid.org/0000-0002-6263-1436</orcidid><orcidid>https://orcid.org/0000-0002-7064-4325</orcidid><orcidid>https://orcid.org/0000-0002-2374-2889</orcidid><orcidid>https://orcid.org/0000-0002-4342-1361</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of gastroenterology and hepatology, 2021-08, Vol.36 (8), p.2275-2284 |
| issn | 0815-9319 1440-1746 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Abundance Alanine Alanine transaminase Body mass index Butyric Acid Eubacterium Fatty liver Fibrosis Gastrointestinal Microbiome Gut microbiota Hepatic fibrosis Humans Intestinal microflora Liver Liver Cirrhosis Liver diseases Microbiota Non-alcoholic Fatty Liver Disease Non‐obese NAFLD Obesity - complications Patients RNA, Ribosomal, 16S rRNA 16S |
| title | Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease |
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