Response to: Comment on: Postoperative opioid administration characteristics associated with opioid-induced respiratory depression: Results from the PRODIGY trial

[...]with respect to anesthetic techniques used, it is important to highlight that the original clinical trial took place on the general care medical and surgical wards during the 48 h post-procedure, where patients were monitored for OIRD using continuous pulse oximetry and capnography monitoring [2]. [...]we consider the impact of operating room anesthetic technique on opioid consumption, and consequently on the occurrence of OIRD, to be out of scope of our current analysis. [...]although we did not control for surgery type, we did provide an evaluation of surgery type within the article supplementary data [3]. While future clinical trials may build on these observations, we hope that our current findings help guide clinicians as they select which opioid(s) to administer to patients during and after surgery and how to best monitor patients to avoid these complications.Role of funding source The PRODIGY trial was funded by Medtronic.Declaration of Competing Interest The PRODIGY trial was funded by Medtronic (Boulder, CO).