Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole

Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole

[Display omitted] Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity agains...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2021-05, Vol.40, p.127944-127944, Article 127944
Hauptverfasser: Blokhina, Svetlana V., Sharapova, Angelica V., Ol'khovich, Marina V., Doroshenko, Irina A., Levshin, Igor B., Perlovich, German L.
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal activity
Hybrids
Lipophilicity
Solubility
Thiazolo-pyrimidins
Triazole
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[Display omitted] Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2021.127944