During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis

During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis

It has been suggested that follicle-stimulating hormone (FSH) plays a role in preventing germ cell apoptosis. We aimed to compare apoptotic rate of boys with cryptorchidism having different levels of FSH in order to investigate its role in apoptosis. Hormonal profiles and testicular biopsies from 30...

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Veröffentlicht in:Journal of pediatric surgery 2021-12, Vol.56 (12), p.2399-2406
Hauptverfasser: Hildorf, Simone, Cortes, Dina, Thorup, Jørgen, Clasen-Linde, Erik, Hutson, John, Li, Ruili
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cryptorchidism
Follicle-stimulating hormone
Germ cells
Gonocyte transformation
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Zusammenfassung:It has been suggested that follicle-stimulating hormone (FSH) plays a role in preventing germ cell apoptosis. We aimed to compare apoptotic rate of boys with cryptorchidism having different levels of FSH in order to investigate its role in apoptosis. Hormonal profiles and testicular biopsies from 30 boys with unilateral cryptorchidism (age range: 4–14 months) were included. Based on FSH level, the boys were grouped into three (3 × 10) having high (>97.5percentile), low (
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2021.02.012