Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility

•A new temperament-brain-attitude circuit has been investigated.•Cingulum is potentially a key tract explaining individual differences in hostility.•HA is a significant susceptibility temperament of hostility. As a textbook manifestation of an aggressive attitude, hostility can pose a serious threat to both an individual's life and the security of society at large. Past evidence suggests that some anxiety-related traits may be more prone to giving rise to hostility. However, many aspects of hostility, such as, determining the susceptible temperament for hostility, the neural basis of hostility, and the underlying mechanisms through which having a susceptible temperament generates hostility in a healthy brain, remain unclear. In this study, we sought to delve into these questions by assessing temperament and brain white matter integrity using self-report questionnaires and diffusion tensor imaging in a sizable sample of healthy adults (n = 357). First, we investigated the relationship between hostility and the four temperaments of the Cloninger model. Then, we investigated which white matter tracts were significantly correlated with hostility using a whole-brain analysis. Finally, we used a mediation analysis to explore the tripartite relationship between vulnerability temperament, the fractional anisotropy (FA) value of the white matter, and hostility. Our results suggest that a harm avoidance temperament may be susceptible to hostility and that the cingulum may be a key white matter region responsible for hostility. Based on these results, we developed a temperament-brain-attitude pathway showing how harm avoidance temperament could affect the brain and ultimately lead to hostility.