Association of preoperative and postoperative CA72‐4 with gastric cancer outcome

Background and Objectives Carbohydrate antigen 72‐4 (CA72‐4) is widely used and has been associated with poor prognosis in gastric cancer (GC), but the prognostic significance of elevated preoperative CA72‐4 that normalizes after resection remains unknown. Methods This retrospective cohort analysis...

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Veröffentlicht in:Journal of surgical oncology 2021-05, Vol.123 (8), p.1699-1707
Hauptverfasser: Wu, Ting, Wang, Chun‐Hua, Wang, Wei, Liu, Li‐Li, Yun, Jing‐Ping, Zhou, Zhi‐Wei
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Sprache:eng
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Zusammenfassung:Background and Objectives Carbohydrate antigen 72‐4 (CA72‐4) is widely used and has been associated with poor prognosis in gastric cancer (GC), but the prognostic significance of elevated preoperative CA72‐4 that normalizes after resection remains unknown. Methods This retrospective cohort analysis was conducted at the Sun Yat‐Sen University Cancer Center (SYSUCC). Consecutive patients (n = 1179) with GC who had undergone curative resection for stage Ⅰto Ⅲ gastric adenocarcinoma. The patients were grouped into three cohorts: normal preoperative CA72‐4 (C1), elevated preoperative but normalized postoperative CA72‐4 (C2), and elevated preoperative and postoperative CA72‐4 (C3). Results In total, 1179 patients were identified. Kaplan‐Meier analysis showed that patients with normal preoperative CA72‐4 had a longer overall survival (OS) (p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26446