Prediction of IDH Mutation Status in High-grade Gliomas Using DWI and High T1-weight DSC-MRI

We aimed to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI) parameters in the noninvasive prediction of the isocitrate dehydrogenase (IDH) mutation status in high-grade gliomas (HGGs). A total of 58 patients with histopathologically proved HGGs were included in this retrospective study. All patients underwent multiparametric MRI on 3-T, including DSC-MRI and DWI before surgery. The mean apparent diffusion coefficient (ADC), relative maximum cerebral blood volume (rCBV), and percentage signal recovery (PSR) of the tumor core were measured and compared depending on the IDH mutation status and tumor grade. The Mann-Whitney U test was used to detect statistically significant differences in parameters between IDH-mutant–type (IDH-m–type) and IDH-wild–type (IDH-w–type) HGGs. Receiver operating characteristic curve (ROC) analysis was performed to evaluate the diagnostic performance. The rCBV was significantly higher, and the PSR value was significantly lower in IDH-w–type tumors than in the IDH-m group (p = 0.002 and