A facile and practical preparation of P-chiral phosphine oxides

A facile and practical preparation of P-chiral phosphine oxides

A practical and cost-effective synthetic method of P-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well contro...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-04, Vol.57 (27), p.3335-3338
Hauptverfasser: Xu, Ronghua, Gao, Zhenhua, Yu, Yiteng, Tang, Yehua, Tian, Duanshuai, Chen, Tian, Chen, Yibing, Xu, Guangqing, Shi, Enxue, Tang, Wenjun
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography
Phosphine oxide
Racemization
Reaction time
Solvolysis
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Zusammenfassung:A practical and cost-effective synthetic method of P-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well controlled by employing a suitable solvent, a low reaction temperature, and an appropriate reaction time.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc00646k