Xenopus models suggest convergence of gene signatures on neurogenesis in autism

Willsey et al. dissect phenotypes associated with in vivo disruption of ten ASD-associated genes using a hypothesis-free, parallelized approach in Xenopus tropicalis. These studies continue to implicate cortical neurons in ASD pathogenesis and suggest a convergence on functions related to neurogenes...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2021-03, Vol.109 (5), p.743-745
Hauptverfasser:	Brennand, Kristen J., Talkowski, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism Autistic Disorder Brain Convergence CRISPR Estrogens Genes Genetic engineering Genomics Genotype & phenotype Neurogenesis Neurogenesis - genetics Neurons Neurosciences Phenotypes Xenopus Xenopus laevis
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Zusammenfassung:	Willsey et al. dissect phenotypes associated with in vivo disruption of ten ASD-associated genes using a hypothesis-free, parallelized approach in Xenopus tropicalis. These studies continue to implicate cortical neurons in ASD pathogenesis and suggest a convergence on functions related to neurogenesis. Willsey et al. dissect phenotypes associated with in vivo disruption of ten ASD-associated genes using a hypothesis-free, parallelized approach in Xenopus tropicalis. These studies continue to implicate cortical neurons in ASD pathogenesis and suggest a convergence on functions related to neurogenesis.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2021.02.017